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Sirolimus

BRAND NAME: RAPAMUNE®

Sirolimus is available as an oral tablet and an oral solution.

What is this medication for?


Sirolimus is a medication used to lower your body’s immune (defense) system. It is used to prevent your transplanted organ from being rejected. It prevents an increase in the number of white blood cells that could attack and damage your new organ.

How should I take this medication?


Sirolimus may be taken with or without food. Taking it with food will decrease stomach upset. Be consistent, if you take it with food, always take it with food; if you take it on an empty stomach, always take it on an empty stomach. 

When having sirolimus blood levels drawn, do not take the morning dose of medication until after your blood sample is taken.


Avoid grapefruit or grapefruit juice while on this medication due to a serious interaction.

Sirolimus can lower the number of your white blood cells, red blood cells and platelets. You may be at an increased risk for infection and bleeding. Regular blood work will be done to check your blood cell counts.


What are some possible side effects of this medication?


Eat healthy, well-balanced meals. Eat foods lower in fat and sugar content. 

 

‎Check your blood pressure regularly. Avoid foods high in salt or sodium.

Signs or symptoms of infection (fever or chills, cough, sore throat or pain or difficulty passing urine)

Signs of bleeding (bruising, tarry stools, vomiting of blood or blood in the urine)

 

‎Signs of decreased red blood cells (weakness or tiredness, fainting spells, light-headedness)

Check with your doctor if you experience persistent weight gain or swelling around the ankles, hands, or eyes. Avoid foods high in salt or sodium. 

‎Practice good oral hygiene. Rinse mouth thoroughly after taking the medication. Contact your doctor if ulcers occur as your dose of sirolimus may need to be reduced. Anti-inflammatory mouth rinses/pastes can be prescribed to resolve mouth ulcers and reduce pain. 

‎Contact doctor immediately if skin rash occurs.

‎Contact doctor immediately if any of the following occur: shortness of breath, chest pain, nagging cough, fever that is not related to another illness.

Taking this medication may increase your risk of skin and other cancers. Please inform your transplant team if you are diagnosed with cancer. For additional information please see section on “Cancer Risk”.



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