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Tacrolimus

[tak-row-lim-us]

BRAND NAMES: PROGRAF®, ADVAGRAF®

Tacrolimus is available in the following formulations:
  • Tacrolimus oral suspension (prepared by transplant pharmacy)
  • Tacrolimus EXTENDED release (ADVAgraf®), a once a day capsule
  • Tacrolimus IMMEDIATE release (PROgraf®), a twice daily capsule

What is this medication for?

Tacrolimus is a medication used to lower your body’s immune system to prevent your transplanted organ from being rejected. It makes your white blood cells weaker so they cannot damage the new organ.

How should I take this medication?

Tacrolimus should be taken with food to decrease stomach upset, but may be taken on an empty stomach if preferred. Be consistent, if you take it with food, always take it with food; if you take it on an empty stomach, always take it on an empty stomach.

Do not take calcium supplements or antacids (Diovol®, Maalox®, etc.) within 2 hours of tacrolimus as antacids may decrease the absorption of the medication by the body. You may take tacrolimus at the same time with stomach acid reducing medications (e.g. ranitidine (Zantac®), pantoprazole (Tecta®) etc.)

Avoid grapefruit or grapefruit juice while on this medication due to a serious interaction.



What are some possible side effects of this medication?

 Presense of these side effects may be a sign of high tacrolimus levels. Report these symptoms to your doctor. These side effects will go away when your doctor adjusts the dose. 

Check you blood pressure regularly. Avoid foods high in salt or sodium.

 

If you are diabetic, make sure you monitor your sugars regularly. Report any numbness or tingling in your hands or feet, increased thirst, dry mouth, fruity odour on your breath, or increased urinary frequency to your doctor.

 


SOURCE: Tacrolimus ( )
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